The article analyzes the groundwater contamination and its spatial distribution in Derna region, north-east Libya. Fourteen groundwater samples were collected and analyzed for PH, EC, TDS, TH, Ca, Mg, Fe, NH4, Cl, NO2 and PO4. Inverse Distance Weighted (IDW) raster interpolation technique of spatial analyst module in ArcGIS software was used to generate the spatial distribution of water pollutants of constituents. The results has revealed that the TDS, T.H Cl and PO4 have exceeded the permissible limit in several samples, and their values were 8000 mg/l, 1700mg/l and 1140mg/l germ per 100cm3 respectively. GIS zonation maps prepared for each element is self-explanatory. The groundwater quality parameters distribution maps have indicated that most of parameters are concentrated on northern and northwestern parts of the region except ph and iron. The quality decreases gradually in the southward and eastward directions, this is due to the high population and urban density and the associated activities in the northern and northwestern parts of the study area, and reflects the existence of correlation among some measurements.