Science, Technology, and Mathematics (STM) are the foundation for scientific and technological breakthrough and also the bedrock upon which the technological advancement of a nation is built. This notwithstanding, it has been observed that many female students do not enrol to study science subjects and the few that do enrolhave to battle with a lot of factors that tend to inhibit their interest, achievement and retention of the STMs. This study is a descriptive survey which tried to examine gender imbalance in the teaching and learning of Physics and to point out the implication of this imbalance on revitalizing Science and Technology for national development.Two hundred and fifty (250) female physics students formed the sample of the study. The instrument for data collection was a researcher’s developed structured questionnaire of the Likert type. The reliability of the instrument was obtained as r = 0.89. Two (2) research questions and two (2) hypotheses tested at 0.05 level of significance guided the study. The data obtained was analyzed using mean and Chi- Square statistics. The study revealed that gender characteristics and attitude of female students towards the study of physics greatly influenced their performance in the subject. This is an important challenge to the achievement of revitalization of science and technology for national development. It was recommended that urgent steps should be taken if the nation is to promote women participation in science and technology for scientific and technological advancement.