This paper seeks to point out the glaring and undeniable need for socio-political and economic liberation in Nigeria. It centers primarily on the prominent role religion, particularly the Christian religion, can play in achieving this noble project and pursuit of socio-political and economic liberation. These issues are discussed under two broad sections. The first section discusses the reality of the need for socio-political and economic liberation in Nigeria, tracing it from the global via the Third World situations. The second section treats the religious factor in achieving the desired socio-political and economic liberation in Nigeria. This is based on the radical potency and capacity of the Church for confronting and transforming the unjust social order. However, maintaining that the Church as a body should not get herself involved in partisan political activism, it outlines some possible functions by which the Church in Nigeria can contribute immensely towards the desired liberation. These include prophetic denunciation of the oppressive mechanism; promoting programmes of raising social consciousness among the masses; practical alleviation of the conditions of the oppressed masses; peace building through positive reconciliation of the oppressed and oppressive members; and personal conversion of the ordinary man. The paper concludes that a combination of the task of spiritual and social liberation enhances the Church, more than any other institution, to influence the socio-political and economic life of the Nigerian society so positively as to restore justice, equity and peace.