Symbolic Interactionism studies have their roots grounded in thought schools based on George Herbert Mead’s, Behaviorism, Darwinism and Pragmatism. Sociologist Herbert Blumer linked Mead’s social psychological approach to sociology and depicted Symbolic Interactionism as a pragmatic method to interpret social interactions. Symbolic interaction is a process shaped through individual behaviors and it is conveyed and interpreted symbolically with the help of daily actions. During the interpersonal interaction process, Symbolic Interactionism studies that concentrate on the origin and interpretation of the meaning, establish a foundation for communication science studies. While Symbolic Interactionism studies are guiding in explaining interpersonal communication processes, however their limited focus on interpersonal communication restrict the research perspective. In addition to this, the potential of Symbolic Interactionism to analyze and explain “individualized mass media” communication studies such as social media, which enable interaction, may be also discussed. Within this framework, this study aims to present the ground set by Symbolic Interactionism for communication science studies and to discuss its analysis potential for other current studies conducted.