Akbar the Great, who was the third ruler of the Mughal Dynasty in India, enlarged the territories of his empire, and developed a strong economy. His hunger for learning led him to devote great attention to the education system, and he was fond of arts and culture. He decided to change his capital from Agra to the village of Sikri, which was later on called Fatehpur Sikri. Artisans from different regions of the country took part in the construction of the city, which lasted fifteen years. Another city, Florence, prospered from the late fourteenth century through the sixteenth century and became a centre of industry, commerce and banking for Europe in this period. The Medici family controlled the city throughout much of the Renaissance even though they had no official position in the government. Many of the members of the house were passionate patrons of the arts, literature and learning, making Florence the richest European culture since ancient Greece. In The Enchantress of Florence, Salman Rushdie brings the East and the West together comparing the lands of Akbar and the Medicis, who were highly interested in art and culture. The purpose of this paper is to examine how Rushdie presents the cities of Fatehpur Sikri and Florence in the sixteenth century through historical and fantastic figures.