The advance of technology today has resulted in a wide adoption of e–learning in healthcare industry and nursing education to supplement a traditional face–to–face learning. Several hospitals in Thailand have been offering courses in English to their nursing staff aiming to encourage them to use English in the workplace. However, restrictions such as excessive work demand and irregular work shift could obstruct nurses from learning in a classroom–based environment. To explore whether or not the registered psychiatric nurses (RPNs) of Nakhon Ratchasima Rajanagarindra Psychiatric Hospital would be interested in learning English through e–learning, the needs assessment survey was conducted. The model of the core adult learning principles or andragogy was adopted as a guide to design and develop questions for the questionnaire and the interview. The purpose of the study was to consider the needs of 70 adult RPNs aged between 25 –60 years old regarding learning how to verbally giving nursing shift reports within the psychiatric wards in English. The questionnaire and semi–structure interview were the main instruments in this study. The questionnaire was divided into 3 parts to gather data pertaining to the demography, basic computer skills, and the development of the e–learning module. The face–to–face semi–structured interview was conducted to 10 RPNs who were randomly selected. Collected data were quantitatively and qualitatively analyzed and interpreted. The quantitative results were described in descriptive statistics and the qualitative results were managed using the method of content analysis. Out of 70 RPNs who were respondents, 63 revealed their interest in joining the e–learning program despite the fact that only 15 had experience learning through e–learning. Gender, age, level of education, year of work experience, and department of work showed no statistically significant difference toward the interest in learning through e–learning. The findings highlighted that adult learners prefer to learn what helps them cope with real–life or work–related situations.