This research explores the dialogue and polemics in which Mary Astell engages John Locke about the place and role of women in the new political kingdom that emerged in Britain after what in British history is known as the Glorious Revolution (1689). Borrowing our critical paradigm from Mikhail Bakhtin’s historiticalicist and dialogic theory, we shall argue that Mary Astell his contemporary took the opportunity that John Locke offers by his critique of Hobbes and Filmer, both of them supporters of absolute monarchy, to make a parallel case in defence of the right of women in order put an end to masculine domination. Her dialogic and polemical readings of Locke, we contend has earned Astell the deserved reputation of being the first proto-feminist to deploy the political theories developed by males in support of female emancipation.